A trans-ancestry association study of Ulcerative Colitis and Crohns' Disease patients with genome-wide or immunochip data from 86,640 European individuals and immunochip data from 9,846 individuals of East Asian, Indian or Iranian descent. Genotyping was performed on a combination of the Affymetrix GeneChip 500K, Affymetrix Array 6.0, Illumina Hap300 and Hap550 BeadChip arrays. Imputation was carried out using IMPUTE2/SHAPEIT approaches against the full 1000 Genomes Project dataset. A total of 144,245 SNPs were available for analysis in the European data set. In total 201 loci were identified as significant in at least one of UC, CRO or IBD, of which 38 were new.
SNPs were excluded as below:-
Samples were excluded as below:-