A genome-wide association study (GWAS) comprising 2,178 affected individuals (cases) and 5,175 controls of self-reported European ancestry, post QC. Individuals with psoriasis (cases) were genotyped on the Illumina Human660W-Quad, and controls were genotyped on the Illumina custom Human1.2M-Duo. Imputation was performed using IMPUTE2. GENECLUSTER was used to investigate possible secondary signals within GWAS associated regions
Of the 9 previously reported loci, 3 reached genome-wide significance in the discovery part of this study. Sixteen previously unreported regions were identified and taken forward for replication with the most strongly associated SNP for each loci being genotyped using the Sequenom iPlex platform. The replication datasets were obtained from across Europe, incorporating 3,174 cases and 5,464 controls. This identified 8 new significant loci of which 6 reached genome-wide significance (P<5x10-8), with multiple signals being detected in 2 of those regions.
- Reported gender and genotyping gender mismatch
- Call rate & Heterozygosity QC
- Relatedness > 5% identity by descent (IBD)
- MAF < 0.0001
- HWE deviation P < 1 x 10-20
GDXHsS00013 meets the following criteria: